If you're running it for just 14 days you can probably get by without it, any longer than that and I think it's worth using Nytol during the cycle. The first time I ran clen I found it really hard to get to sleep so I ran Nytol and that solved the problem. It certainly don't think it would do you any harm to use it for a couple of nights in your clen run..

If you plan on running another beta agonist immediately after the clen run (i.e ephedrine) then it would definately be a good idea to run it at the end of the 14 days for a week..

On another note, I wouldn't take more than 100mg at a time. I tried 150mg before bed a few times to try and clear out my beta recepetors in one go rather than doing it over a week. It made me really twitchy and itchy at this dose and actually made it almost impossible to sleep. I don't know why this happened (I might just have an unusual reaction to it at that dose) but just thought you should know...